Stuart - Disappointed none of that helped. Am pretty sure that everyone with this problem got there in the end via this forum. Presume you tried "Fleasomes" notes -
just in case -
1. Choose Start > Settings > Control Panel (Windows 2000) or Start > Control Panel (Windows XP).
2. Choose Tools > Folder Options and click the View tab.
3. Make sure that Hide Protected Operating System Files is deselected.
4. Select Show hidden files and Folders.
5. Uninstall Cool Edit Pro or Cool Edit 2000.
6. In Windows Explorer, navigate to C:/Documents and Settings/[user]/Application Data.
7. Delete the Syntrillium folder, if one exists.
8. Reinstall Cool Edit Pro or Cool Edit 2000.
9. Follow steps 1-3 to reselect Hide Protected Operating System Files.
One other thread over in Nuts n' Volts forum might be worth a look - 3 pages !!
http://www.servomagazine.com/forum/viewtopic.php?t=4176&highlight=ce2000
Let us know current state of play.....
Cheers.
ps - what's methodone? - couldn't even find it via Google.